The effects of vitamin E supplementation on lipid profile in menopausal women; a randomized double-blind controlled trial

Background: Menopause is associated with changes in lipid profile and is knownas an oxidative stress risk factor. Different therapeutically strategies have beenused in the case of controlling the menopause complications. Vitamin E as agreat anti-oxidant possibly can be effective on lipid per-oxidation in menopausalwomen. We aimed to evaluate the effect of vitamin E supplementation on lipidprofile of menopausal women.Methods: This double-blind placebo-controlled randomized cross-over PhaseI/II trial study was designed with two -۴week intervention periods and a -۸daywashout period between treatments. Eighty-three natural menopause womenwere participated in the study. The randomized block allocation were used andenrolled women divided in group A (n=۴۱) and group B (n=۴۲). In phase I onegroup was given ۴۰۰ IU/day vitamin E capsule and another group was givenplacebo capsule for ۴ weeks. Then they entered an -۸day wash-out periodsubsequently the phase II for a period of -۴week started in which the groupthat received vitamin E capsule was given placebo (E-P) and the group receivedplacebo was given Vitamin E (P-E). The plasma lipid profile (LDL-C HDL-C TCand TG) were assessed before and after of the intervention in each phase and ingeneral by gathering vitamin E and placebo groups in the two phases separately.The measurement of lipid panel was performed by enzymatic colorimetricmethod. The study results presented as mean ± SD and median (quartile).Results: The levels of LDL-C HDL-C TC and TG before the intervention betweenP-E and E-P groups by Mann-Whitney U tests no remarkable difference wereseen. Also lipid profile measurement before and after intervention in Phase Iand II of P-E group did not show significant differences. However in E-P group itwas revealed that the TG factor before (۵۳.۵۲ ± ۱۴۱.۷۴ mg/dl) and after (۱۶۷.۴۷۷۱.۳۲ ± mg/dl) intervention within phase II had a considerable difference(P=۰.۰۱۰). No significant differences were seen in the lipid profile mean andchanges before and after intervention between vitamin E and placebo receiversin both phases.Conclusion: The study results revealed that vitamin E supplementation had noremarkable effects on lipid profile levels in menopausal women. Widespreaduse of vitamin E supplementation for protection and control the impact ofmenopause does not appear warranted. Thus further study with larger samplesize different duration and doses are necessary.

کلیدواژه ها:

Antioxidant ، Lipids ، Menopause ، Vitamin E