Modified Hollow Fiber Membrane with Silver/Multiwall Carbon Nanotube/Polyaniline Nanocomposite as a Sensing Element for Voltammetric Measurement

Electrochemical techniques are powerful analytical techniques that used successfullyfor determination types of pharmaceutical samples. These techniques are simple, effective, lowcostand reliable with high sensitivity, accuracy, precision and wide linear dynamic range [۱].Carbon-based sensors have been extensively used in the electrochemical studies. Carbonnanotubes are suitable for electrodes preparation due to their high electrocatalytic activity, highchemical stability and low fouling. In addition, multiwall carbon nanotubes (MWCNTs) are widelyapplied as the appropriate modifiers in preparation of some electrodes because of their ability toimprove the facility of electron transfer between electro-active species and electrodes [۲, ۳]. In۲this research, the hollow fiber membrane was modified with silver/multiwall carbonnanotube/polyaniline (Ag/MWCNT/PANI) nanocomposite by electrophoretic deposition (EPD)method and used as the sensor for voltammetric measurement of dipyridamole (DIP) in aqueoussolution. The surface morphology and electrochemical properties of the electrode was evaluatedby SEM, TEM, EDX, XRD and EIS. The electrochemical efficiency of the proposed electrode wasinvestigated with cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniquesfor determination of DIP in aqueous solution. The limit of detections (LODs) and linear dynamicranges (LDRs) for DIP were obtained ۰.۰۰۱-۵۰ μM and ۱.۰ × ۱۰-۳ μM, respectively. The sensorwas successfully employed to determine DIP in real samples such as pharmaceutical formulations.

کلیدواژه ها:

Electrochemical sensor ، Hollow fiber membrane ، Ag/MWCNT/PANInanocomposite ، pharmaceutical products ، DIP ، EPD