Effect of eight weeks of swimming training and CBD oil consumption on PI۳K and ERK gene expression in the heart tissue of rats with myocardial infarction
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 59
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شناسه ملی سند علمی:
JR_SKUMS-24-2_002
تاریخ نمایه سازی: 28 تیر 1402
چکیده مقاله:
Background and aims: Cannabidiol (CBD) oil consumption can positively contribute to controlling the cardiovascular risk factors. Exercise
can also be effective in rehabilitating myocardial infarction by strengthening muscle tissue. This study, therefore, aimed to evaluate the
effect of eight weeks of swimming training together with CBD oil consumption on PI۳K and ERK gene expression in the heart tissue of rats
with myocardial infarction.
Methods: In this experimental trial, ۲۵ ovariectomized rats with myocardial infarction were divided into five groups, including ۱) control,
۲) MI ۳) MI +training, ۴) MI + supplement, and ۵) MI +training+ supplement groups. Myocardial ischemia was induced by subcutaneous
injection of isoproterenol (۵۰ mg/kg intravenously) in myocardial infarction rats. Groups ۳ and ۴ received ۵۰ mg/kg CBD as gavage on a
daily basis for eight weeks, and groups ۲ and ۴ performed swimming training five days a week. One-way analysis of variance (ANOVA)
with Tukey’s post hoc test was performed to analyze the findings (P < ۰.۰۵).
Results: Induction of myocardial infarction contributed significantly to reducing PI۳k and ERK gene expression in the heart tissue (P = ۰.۰۰۱).
However, swimming training with CBD oil consumption contributed significantly to increasing PI۳K (P = ۰.۰۰۳) and ERK (P = ۰.۰۰۱) gene
expression in the heart tissue of rats with myocardial infarction.
Conclusion: Seemingly, swimming training along with CBD oil consumption had more favorable effects on improvement of PI۳K and ERK
gene expression levels in myocardial infarction than either alone. Therefore, it was recommended that CBD oil together with swimming
training should be employed when dealing with myocardial infarction.
کلیدواژه ها:
نویسندگان
Mostafa Safian Boldaji
Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Khosro Jalali Dehkordi
Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Farzaneh Taghian
Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran