Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis

Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. Among the new markers, preptin seems to play a significant role in metabolic disorders. Objective: This meta-analysis was conducted to determine the relationship between circulating preptin levels and PCOS. Materials and Methods: A systematic review and meta-analysis was performed to identify relevant articles in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and the Google Scholar search engine, using a predefined search strategy. A random-effects model was used to combine standard mean difference (SMD) and ۹۵% CI to compare results between groups. Meta-regression and subgroup analysis were also performed to reveal the sources of heterogeneity. Results: The meta-analysis encompassed a total of ۸ studies and ۵۸۲ participants. The results indicate a statistically significant association between PCOS and serum preptin levels, with a pooled standardized mean difference (SMD = ۱.۳۵; ۹۵% CI]: ۰.۶۳-۲.۰۸; p < ۰.۰۰۱). Further analysis suggested a significant difference in serum preptin levels between women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = ۲.۴۰; ۹۵% CI: ۱.۱۷-۳.۶۳; p < ۰.۰۰۱) within the subgroup. Conclusion: Our meta-analysis shows that increased serum preptin levels are associated with PCOS, suggesting that preptin may be related to the pathogenesis of PCOS and may be recognized as a novel diagnostic biomarker for PCOS. However, further studies are needed to confirm our results.

کلیدواژه ها:

Polycystic ovary syndrome ، Proinsulin-like growth factor II ، Preptin ، Meta-analysis. ، سندرم تخمدان پلی کیستیک ، فاکتور رشد شبه انسولینی II ، پرپتین ، متاآنالیز.