The role of inflammatory cytokines (IL-۱ and IL-۶) in the different stages of Covid-۱۹ (mild, severe, and critical)

سال انتشار: 1401
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 85

نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:


تاریخ نمایه سازی: 3 خرداد 1402

چکیده مقاله:

Introduction and objective: Covid-۱۹ causes inflammatory reactions in the body. The purpose of this study was to review studies conducted to assess serum concentrations of inflammatory cytokines (IL-۱ and IL-۶) in patients with COVID-۱۹ at various stages of the disease.Method of Evaluation: A systematic search during the years ۲۰۲۱-۲۰۲۲ using the keywords COVID-۱۹, SARS-CoV-۲, IL-۶, IL-۱, CRP, Mild stage, Severe stage, Critical stage, Cytokine storm, Tocilizumab, Anakinra was performed in PubMed and Google Scholar databases.Results: A cytokine storm reflects an over-production of immune and inflammatory cells and their cytokines (IL-۱ and IL-۶). Studies have shown that cytokine storms are a primary cause of acute respiratory distress syndrome. In the presence of this unexpectedly emerging novel infectious disease, it is vital to perceive immune-inflammatory parameters that might expect the disorder severity and the prognosis essentially for directing medical care. A review of the studies shows that patients with COVID-۱۹ have been classified as mild, severe, and critical. Studies have also shown that the measurement of serum levels of IL-۶ and IL-۱ in patients with COVID-۱۹ shows a high level of these cytokines at each stage. In addition, IL-۱-induced IL-۶ assists in the synthesis of liver C-reactive protein (CRP) in acute phase responses. In recent studies, IL-۶ levels were significantly higher in critical COVID-۱۹ and severe cases of COVID-۱۹ compared to the mild group, suggesting that this is an independent predictor of coronavirus disease. Anakinra and Tocilizumab are beneficial in reducing mortality in COVID-۱۹ patients; however, there is limited information on safety and efficacy.Conclusion: As a result; studies suggest that reduced innate antiviral defenses coupled with the production of exuberant inflammatory cytokines are the determining and driving functions of COVID-۱۹. This study reviews studies that have investigated the role of high levels of these cytokines in the severity of the disease in patients with COVID-۱۹ and the inhibitory function of Tocilizumab and Anakinra in preventing mechanical ventilation and patient mortality.

کلیدواژه ها:


Mina Ghofrani Nezhad

Bachelor's student, Nursing, Toxicology and Drug Abuse Research Center, Birjand University of MedicalnSciences, Birjand, Iran

Sajad Chamani

Master of Immunology, Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran

Ali Naghizade

Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran