The effect of oral and infusion intake of branched-chain amino acids (BCAAs) after gastrointestinal surgeries: A systematic review

Introduction: Branched-chain amino acids (BCAAs; leucine, isoleucine, and valine) areessential amino acids involved in protein malnutrition and sarcopenia. This study aims toinvestigate the effect of oral and infusion intake of branched-chain amino acids (BCAAs) aftergastrointestinal surgeries.Search Method: Scientific reports were searched on the PubMed and Scopus websites fromMarch ۱, ۱۹۹۲, to March ۳۱, ۲۰۲۰. These studies included data from oral and infusion intakeof branched-chain amino acids (BCAAs) after gastrointestinal surgeries.Result: One hundred and ninety-three studies on branched-chain amino acids (BCAAs) andsurgery were identified. Eleven relative publications were eligible for systematic review.Finally, after applying the inclusion and exclusion criteria, ۶ randomized clinical trials andclinical trials were found and the following results were obtained from oral and injectableintake of branched-chain amino acids (BCAAs) after gastrointestinal surgeries:The temperature in the BCAAs group was significantly higher than that in the normal salinegroup (P = ۰.۰۱۴).Shivering in the BCAAs group was significantly lower than in the normalsaline group (P = ۰.۰۲۷).The plasma-free fatty acids concentrations in the BCAA group werelower than in the normal saline group after surgery.Intake BCAAs showed a correlation withmeasures of insulin sensitivity and glucose tolerance after the RYGB.In one study Serum levelsof alanine aminotransferase, aspartate aminotransferase, and ammonia did not differsignificantly between the BCAA group and control group. There was no difference betweenthe groups in serum hemoglobin levels after the operation.After a period of BCAAs TPN, laboratory data, including white blood cells (WBC), C-reactiveprotein (CRP), alkaline phosphatase (ALK-P), and gamma-glutamyl transferase (gamma-GT)levels, were significantly between BCAAs groups and placebo (all P < ۰.۰۵).The BCAAsinfusion intake by TPN can preserve a patient's serum visceral protein (albumin andprealbumin) and positive nitrogen balance better than standard TPN (all P < ۰.۰۵).Conclusion:According to the findings of this review, oral and infusion BCAA inhibited fatmobilization and have positive effects on serum albumin, glucose, insulin sensitivity, whiteblood cells (WBC), C-reactive protein (CRP), alkaline phosphatase (ALK-P), and gammaglutamyltransferase (gamma-GT) levels after gastrointestinal surgeries.Our observations showthat BCAA-enriched TPN may be beneficial in improving the nutritional status and reducingpostoperative complications for malnourished patients undergoing gastrointestinal surgeries.

کلیدواژه ها:

BCAAs ، branched-chain amino acids ، gastrointestinal surgeries