The perfume industry is one of the most important chemical industries. The quality of a perfume and its acceptability by the consumer depends on many and in some cases intertwined factors. Even the qualitative and perceptual factors such as color, hue and viscosity are also important in customer attraction. In addition to the quality of the raw materials used, such as the purity and authenticity of the main perfume extract or extracts, the chemical composition of the fixator solvents is also extremely important. Each specific perfume extract, depending on the volatility and boiling point, the desired temperature range to be use and the so-called odor line it creates, requires the combination of special fixing solvents to ultimately create the desired quality of the final perfume product. Of course, the price of pure solvents and the cost and economy of preparing and mixing solvents are also important. In this research, ۶ extracts (۲ so-called strong extracts, i.e. Rosemary and Chypre, ۲ medium extracts, i.e. Invictus and Gievenchy, and ۲ weak extracts, i.e. Creed Aventus and Platinum) were selected and using ۵ specific environmentally friendly solvents, combinations for each category of extracts (base perfumes) were prepared by the RSM (Response surface Methodology) approach and studied. Parameters such as the cost, the durability of the fragrance, the desirability of the scent line, the absence of stains on the clothes, the absence of undesirable smell after mixing of the perfume with fixing solvents, were studied in the temperature range of ۰ œC (cold seasons) to +۳۸ œC (hot seasons) and relative humidity of ۵ to ۹۸% (very dry to completely humid environment) were studied. The results showed that for each category of basic perfumes, it is necessary to choose an optimal combination to achieve the majority of desirable parameters, but in a few cases, it is not possible to have all the desired parameters together, which is a quite normal case. In general, the method developed in this research can be very helpful in designing a mixture of optimal stabilizing solvents and making specialized perfumes depending on specific geographic and weather conditions, and also, It can be considered as an illuminating factor in the further way to understand, from a molecular point of view, the mutual interaction of solvents in terms of creating desirable aromas.