SNHG۶ ۲۰۳ Transcript Could be Applied as an Auxiliary Factor for more Precise Staging of Breast Cancer

Background: Nowadays long non-coding RNAs are known as interesting functional part of the transcriptome. LncRNA SNHG۶ was reported to be expressed more in breast cancer tissues than non-tumor ones. As a frequent cancer among women, breast cancer treatment needs applied biomarkers for fast prognosis and diagnosis. SNHG۶ RNA and its splice variants could be considered as molecular biomarkers for the breast cancer well-timed treatment. Methods: RNA extraction from ۳۵ breast cancer tissues and their relative non-tumor tissues was done and cDNAs of the RNAs were synthesized and then RT-qPCR was performed. Relative expression of SNHG۶ ۲۰۲ and ۲۰۳ was studied in breast cancer samples. Results: The expression patterns of SNHG۶ ۲۰۲ and ۲۰۳ variants were different. Difference in the expression pattern of SNHG۶ ۲۰۲ was significantly remarkable in relation to the HER۲ status of tumor samples. SNHG۶ ۲۰۳ was expressed in tumor and non-tumor tissues differentially and the expression difference was significant. Also, this transcript exhibited significant expression difference in different stages of the studied breast tumor samples. Conclusion: It could be stated that SNHG۶ ۲۰۳ transcript might be considered as a prognostic and staging biomarker in breast cancer studies and treatment.

کلیدواژه ها:

breast cancer ، Biomarker ، Prognosis