The effects of aerobic training on bone mineral density in type ۲ diabetic rats

Aerobic training (AT) has been known to be effective in maintaining and improving bone strength, which is based on bone mineral density (BMD) and bone quality. However, it is not clear whether AT is effective in improving bone strength in patients with type-۲ diabetes mellitus (T۲DM), who have a high risk of fracture. Therefore, we tested the effects of a ۱۲-week AT regimen in T۲DM model rats. Thirty-six male Wistar rats (۱۴ weeks old) were randomly allocated into three groups including diabetic training (DT) group, diabetic (D) group and control (C) group. At fifteen weeks-of-age, diabetes was induced by an intraperitoneal injection of Nicotinamide-Streptozotocin. Rats in the DAT group carried out an ۱۲-week exercise program on a motorized treadmill (۲۷ m/min for ۲۰-۶۰ min/day), whereas the C and DC remained sedentary in their cages. Body composition and bone density throughout the body were assessed using a dual X-ray energy absorption at the beginning and after the intervention. Data were analyzed using SPSS statistical software and one-way analysis of variance and Tukey post hoc tests. At the end of the intervention period, bone mineral density in the thigh and lumbar spine were significantly lower in DT and D groups compared with C group (P<۰.۰۱). Bone density in the thighs and lumbar spine were significantly lower in D group compared with DT and C group (p < ۰.۰۵). These results indicate that the ۱۲ week AT regimen effectively increased BMD and improved bone quality in T۲DM model rats. Our findings suggest that AT may have the potential to improve bone strength and reduce fracture risk, even in patients with T۲DM.

کلیدواژه ها:

Bone mass ، bone quality ، Resistance training ، type-۲ diabetes mellitus