ASSESSMENT OF RELATION BETWEEN MICROALBUMINURIA AND ISCHEMIC ELECTROCARDIOGRAM IN IRANIAN GENERAL POPULATION

Abstract    BACKGROUND: Enhancement of albumin exertion in urine increases the risk of renal and ischemic heart diseases (IHD). We assessed the association of urine albumin and sub-clinical IHD in a random sample of Iranian general population.    METHODS: The random sample in general population in Isfahan County was recruited to the cross-sectional study. From the all sample blood pressure and lipid profile were assessed and morning urine spot was measured for albumin and Creatinine. Microalbuminuria was defined either Albumin-Creatinine Ratio (ACR) was ۳۰-۳۰۰mg. Also, the standard ۱۲ lead electrocardiogram (ECG) was carried out for all participants. The ECG pattern was divided to two categories; normal or ECG with ischemia. The logistic regression model was determined the odds of albuminuria for ischemic changes in ECG.    RESULTS: ۹۹۹ subjects, age ۳۵-۷۰ years, participated to study. From all, ۴۰.۸% were male. Microalbuminuria was detected in ۸% and sub-clinical ECG ischemic changes were found in ۲۳.۴%. The most frequent ischemic change was T wave inversion. The mean urine albumin levels in subjects with normal ECG was ۹.۶±۱۴.۶ mg/ml and in ischemic group was ۸.۵±۱۲.۲ mg/ml and they did not have statistically different. The odds ratios of neither Albumin-Creatinine ratio nor microalbuminuria were in significant range for risk to ischemic changes in ECG of apparently healthy participants. They was consecutively OR=۰.۹ (۰.۵۱-۱.۶), OR=۰.۹۹ (۰.۹۸-۱.۰۰۴).     CONCLUSION: Our finding didn’t declare any association between ACR and IHD. Because of showing this association in the other study; it needs more exploration regarding to association between microalbuminuria and cardiovascular diseases incidence.      Keywords: Ischemic heart diseases, electrocardiogram, Albumin-Creatinine Ratio, Urine Albumin