Influence of nandrolone decanoate administration on serum lipids and liver enzymes in rats
محل انتشار: مجله آریا آترواسکلروز، دوره: 11، شماره: 4
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 177
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شناسه ملی سند علمی:
JR_RYA-11-4_007
تاریخ نمایه سازی: 2 شهریور 1401
چکیده مقاله:
BACKGROUND: Anabolic-androgenic steroids have been associated with several side effects range. This experimental study was conducted to evaluate the effects of nandrolone decanoate (ND, an anabolic steroid) on lipid profile and liver enzymes in rats in Iran. METHODS: Forty adult male and female of Wistar strain rats were randomly assigned to four groups of ۱۰ animals each: male control, female control, ND - male treated (۱۵ mg/kg b.w./day), and ND - female treated (۱۵ mg/kg b.w./day). Serum concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured in all studied groups. RESULTS: Treating rats with ND (case group) resulted in a significant elevation of TC (۶۹.۴ ± ۸.۷), TG (۱۰۱.۶ ± ۳۲.۹) and ALT (۷۲.۲ ± ۱۳.۸) and significant reduction of LDL (۶.۴ ± ۲.۶) and AST (۱۳۸.۷ ± ۱۹.۴) as compared to control group in female rats. ND supplementation (case group) significantly increased TC (۶۴.۴ ± ۶.۲), AST (۲۵۵.۰ ± ۳۲.۰), and ALT (۸۴.۳ ± ۳.۸) in comparison with the control group in male rats. CONCLUSION: Overall, our result indicated that the ND use can cause a negative effect on lipid profile and liver enzyme in rats.
کلیدواژه ها:
نویسندگان
Mohammad Reza Samieinasab
Assistant Professor, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
Mohammad Reza Shahraki
Associate Professor, Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Fatemah Samieinasab
Ayatollah Golpayegani Hospital, Qom University of Medical Sciences, Qom, Iran
Somayeh Najafi
Msc Student, Cardiac Rehabilitation research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran