Investigation of SDCCAG۸ gene in COLON ADENOCARCINOMA and the possibility of rs۷۶۹۶۹۸۲۲۹ in hsa-mir-۴۵۰b-۵p

Introduction: Colon cancer is a type of cancer that starts in the colon or rectum.The large intestine formsthe organs of the lower gastrointestinal tract.There is more than one type of colon cancer.There are cells indifferent parts of the gastrointestinal tract that can lead to colon cancer.The most common type of coloncancer starts with adenocarcinoma.Adenocarcinomas form inside the cells that make up the lining of the largeintestine or rectum.Cancer may be caused by genetic mutations that can be inherited or acquired.Thesemutations are not a guarantee of colon cancer, but they do increase the risk.The SDCCAG۸ gene encodes acentrosome-related protein.This protein may be involved in the organization of the centrosome during theinterphase phase,and mitotic mutations in this gene are associated with renal retinal ciliopathy.Materials and methods: At the NCBI site, the SDCCAG۸ gene (involved in interphase and mitosis) wasselected(۲).At the GEPIA۲ site,the expression of this gene was examined,and at the MIRWALK site, themicroRNAs that acted on this gene were studied,and at LNCRNASNP۲, this microRNA was examined forexpression in COLON ADENOCARCINOMA and finally the SNPs affecting this microRNA were examinedat the MIRNASNP site.Discussion: SDCCAG۸ gene is more expressed in tumor patients.MIRNA (has-mir-۴۵۰b-۵p) that wasselected had a score: ۰.۸۵ and np:۱۶, which has a great effect on the SDCCAG۸ gene.This MIRNA had anexpression of ۷.۱۸ in COLON ADENOCARCINOMA.And many SNPs affect this MIRNA.Conclusion: SNPs are high-density natural sequence variations in genomes and are considered as a majorgenetic source of phenotypic variation within a species and are considered important genetic markers.Based on previous research, it is predicted that SNP rs۷۶۹۶۹۸۲۲۹ will be created between a gene or MIRNAand cause a functional disorder.

کلیدواژه ها:

Colon ، cancer ، lnc ، snp ، gene