Genetic of Endometriosis & Female Infertility

Endometriosis is the most common genetic cause of female infertility, in which the endometrial tissue of the uterus falls out of place, such as the ovary, causing pain, adhesions, and injury, and prevents the egg from moving and fertilizing. Causes of the disease include the return of menstrual blood to the pelvis, which contains endometrial cells, and a history of uterine surgery in which endometriosis cells grow at the wound site and the growth of embryonic cells in the mother's uterus. Genetic factors: Increased expression of mmp۲ and mmp۹, which enable endometrial tissue to digest ecm and increase adhesion strength. Existence of nanocoding microrns that express these genes by inhibiting translation by binding to the untranslated region of the ۳ mrna target, and their improper expression is associated with functional impairment, as well as mirna۱۴۳, which induces cancer cell metastasis by inhibiting fndc۳b ogen. It causes adhesions and endometriosis. The presence of a series of gene markers increases the risk of disease and their increase indicates the severity of the disease. The two polymorphisms rs۴۷۰۵۳۴۲ and rs۴۱۲۹۱۹۵۷ are located in the promoter of mirna۱۴۳ gene and have an effect on disease expression.