A Review of the practical effects of ginseng and the treatment of disease

Ginseng called the king of all herbs. Ginseng includes panax genus of Araliaceae family. the word panax means "all heal". In Greek. Ginseng is originated from the Chinese word "Jen Seng ", meaning man-herb, because the shape in root. Of the plant resembles a humanoid form. Ginseng has been used as a traditional herbs in Asian countries for thousands of years.it contains a large number of Active ingredients including steroidal saponin, protopanaxatriols, and protopanaxatriols. Of The most pharmacological and medical studies of ginseng have focused primarily on ginsenosides and major ginsenoside such as Rb۱, Rb۲, Rc, Rd, Re and Rg۱. in recent decades, the antioxidative and anticancer effects of ginseng, in addition to its effects on improving immunity, energy and sexuality and combating cardiovascular disease, diabetes mellitus and neurological disease. ginseng has different activities that include antioxidant activity (ethanol and methanol extracts of ginseng leaves have the potential to scavenge free radicals, levels of glutathione peroxidase and superoxide dismutase -like antioxidant enzymes are increased by ginseng), anti-inflammatory activity ginsenosides Re and RP۱ can suppress the NF‐κβ signaling pathway and ginsenoside Rc can inhibit the expression of macrophagederived cytokines), antimicrobial activity(against virus, different bacteria, this herb has activity against H۱N۱, H۳N۲ and H۹N۲ influenza viruses), anti-cardiovascular disease activity with decrease of thrombin induced platelet aggregation, decrease serum lipid level, decrease voltage -independent ca² chanel ), anti-obesity(decrease of adipogenesis and lipogenesis, plasma TG level, decrease cholesterol), antidiabetic(compound K, an active metabolite of ginsenosides can stimulate insulin secretion by primary cultured islets).anticentral nervous system disorder effect(ginsenosides RB۱, RB۲, RB۳, Rc, Rd, Rg۱, Rg۲ and Rg۳ have significant therapeutic effects such as memory, anexiety depression, epilepsy, stroke. amyotrophic lateral sclerosis, AD, PD and Huntington disease), Energy and Sexuality with improved altered blood chemistry and sperm kinematic values and enhanced muscular glycogen level, glucose -۶-phosphate dehydrogenase, lactate dehydrogenase activity, anticancer activities with inhibits TNF-α production, inhibits capillary genesis, inhibitsoncogene c-fos, c-myc, protection against oxidative stress. incomplete metabolism of the skin causes problems such as acne, eczema and dry skin. one of the properties of ginseng is to increase blood circulation in the skin clear and beautiful. ginseng has side effects in some cases these include headache, digestive and sleep problems and in pregnant women and not recommended for people with diabetes, kidney, breast, uterine, ovarian, pregnant women andchildren.

کلیدواژه ها:

Ginseng ، treatment ، immunity ، disease