The effect of probiotics on the improvement of colorectal cancer

Probiotics are living Microorganisms that play an important role in protecting the host. Gastrointestinal microbiome is a factor. In establishing homeostasis. of colorectal cancer is one the most important causes of mortality in the world.. Researchers have identified lactic acid bacteria as Saccharomyces and candida, are the most important probiotics. profitability effects of LAB and its derived. Bioactive metabolites include improving gastrointestinal disorders such as inflammatory bowel disease (IBD) improving urogenital disorders, improving lactose metabolism, antidiabetic activities, immunomodulation properties, anti –carcinogenic activities , improving lactose metabolism and promoting cancer therapies. Probiotics are able to regulate Cancer signals. use of whole living cells, supernatants, heatkilled cells, cytoplasm and cell wall of lactobacilli have properties such as anti-proliferativeand pro-inflammatory. .Probiotics are able to introduce apoptosis, inhibit mutagenic activity, reduce cancer gene expression, induce autophagy, activate tumor inhibition and inhibit metastasis. The anticancer properties of probiotics are mostly due to metabolites the regulation of host physiological and metabolic function. many of postbiotics cause regulating immune responses, reducing cell viability, binding to mutagenic and carcinogenic constituents,triggering pro-apoptotic cell death pathways, reducing microbial Translocation, increasing apoptosis and necrosis, increasing tumor cell death via autophagy, anti -proliferative activity against Cancer cells, decreasing metalloproteinase-۹ activity and inhibiting cancer invasion.but lactobacilli induced cytokines, such as interferon-gamma, stimulate natural killer cells and increase antitumor properties of lactobacilli.in this article, we have tried to discuss the therapeutic effect on probiotics.

کلیدواژه ها:

Colorectal cancer ، ، Probiotic ، Lactobacilli ، Saccharomyces