Non-coding RNAs and biogenesis Multiple Sclerosis

Multiple Sclerosis (MS) is a chronic immune deficiency in the central nervous system (CNS) with several genetic and environmental factors, whose pathogenesis is associatedwith genes with regulatory role in the immune system. Recently, long non-coding RNAs (LncRNAs) have been reported to regulate immune responses and gene expression, and show the tissue specificity and complexity of biofunctions. Various studies have suggested that the aberrant expression of LncRNAs is an underlying factor in the incidence of MS and that the analysis of the expression profile of these molecules can be a good candidate as a specific MS biomarker for preventing the course of the disease or responding to treatment. In this research, we will review recent studies to explore the role of LncRNAs in the processes leading to MS disease

کلیدواژه ها:

Biogenesis RNAs ، MS ، Gene regulation ، Biomarker