Prep aration of Poly Pho sphoric A cid Impregnated on Silica Gel (PPA-SiO۲) and study of its activity for t he Synthe sis of ۱,۲,۴ ,۵-Tetrasubstituted Imidazoles

Multi-component, one-pot react ions are highly import ant because of their w ide range of application in phar maceutical libraries for drug disco very.In five-membered heterocycles, imidazoles moiety is present in a wide range of naturally molecules and uses in preparation of fungicid es,herbicide s. [۱-۳] in recent years solid-sup ported rea gent, such as silica gel supported acides, co uld be used as a multipu rpose acid c atalyst. [۴-۵ ] in this study we uses of PPA-SiO ۲ as solid ac id catalyst a nd use of microwave ir radiation.

کلیدواژه ها:

Multicomponent reactions ، te trasubstitut ed imidazoles ، poly phosphoric acid supported silicagel