Polyme r/KIT-۶ nanocompo site: synthesis, characterization and controlleddrug r elease

Recently, cubic mesoporoussilicas w ith three- dimensional structure have attr acted mucha ttentionfor potential a pplications in pharmaceutical. Ryoo et al. reported a newcubic mesoporous silicamaterial called KIT-۶, whic h exhibited a three-dimensional cubic Ia۳dsy mmetric structure with an interp enetrating bicontinuous network of channel s [۱]. Thismesoporous silica, KIT-۶ possesses large readily tunable pores with thick pore walls, highh ydrothermal stability, high specific surface area , and a large pore volu me which c an act aseffic ient drug delivery carriers. In addition, the three di mensional polymer network struct ureswith ch emical and physical cro sslinking a re gaining increasing popularity as drug carrie rs forcontrolled release of drugs d ue to their biocompatibility and resemblance with natural livingtissues more th an any other class of s ynthetic biomaterials. D rug release from polymerhydrogel carrier, mai nly occurs due to polym er swelling in the body fluids as a result ofincrease in segm ental mobility of polym er [۲,۳].

کلیدواژه ها:

Mesoporous silic a ، Drug deli very ، Poly ( N-Vinyl-۲-Pyrrolidone) ، Nanocomp osite