E valuation of a Coupling Strategy to Obtain Biofunctional-Magneti c Nanoparticle for Bi odetection

Rapid and sensitive determ ination of pathogeni c bacteria is extremely important in biotechnology, m edical diagnosis and the current fight against bioterrorism [۱]. It is possible to cap ture and d etect biomolecules by the movement of mag netic nanoparticles under an external magnetic field. There are various methods to synthe size magne tic nanopar ticles Among these methods, co-pr ecipitation is a general and simple technique for synthesis of magne tic nanoparticles. Diffe rent chemi cal groups ( carboxyl, amino, aldehyde, etc.) on the surface of nanopartiles can be used to covalently immobilize oligonucleotide probes to increase affinity of nanoparticles to the desired target.

کلیدواژه ها:

“Ma gnetic Capture Hybridization ، Iron Oxide Nanoparticle ، Oligonucl eotide Probe ، Diagnostic”