E lectrochemical determinati on of acetaminophen in the presence of ascor bic acid and propranolol using meta lic Cu na noparticles- Schiff base modified ca rbon pas te electro de

Acetam inophen, o r paracetamol (N-acetyl-p-amin ophenol), is an antipyretic an d minor analgesic drug that practically has no anti-inflammatory action. It is used for the relief of mild to moderate pain associated with head aches, back aches, arth ritis and postoperative pains,reducti on of fevers of bacte rial or viral origin [۱]. Therefo re, the development of fast, sensitive and accurate meth ods for determining acetaminophen conte nt are of clinical exigenc y. Construction of electrochemical sensors using modi fied electrodes continues to be an area of great in terest and a relatively large amount of electrochemical research h as been devoted to the dev elopment a nd application of these sensors for the analysis of biologically active compounds. The fabrication of electrodes m odi¿ed with nanoparticles has been the focus of recent attention owi ng to enhan cement of the respon se signal, i ncreased sensitivity and better reprodu cibility [۲, ۳]. The pr esent work a carbon paste elect rode modified with metalic Cu nanopa rticles and Schiff bas e was developed for the individua l and simultaneous determination of acetamino phen (AC), ascorbic acid (AS) and propranolol (PR). The electroc hemical behavior of these three molecules was in vestigated employin g cyclic voltam metry (CV), differentia l pulse volt ammetry ( DPV) and chronocoulometry (CC).

کلیدواژه ها:

Modified electrode ، metalic Cu nanoparticles ، Acetaminophen ، proprano lol