Decoding linagliptin protective effects on kidney and cardio by investigating its transcription factors (TFs)-micro RNAs -target genes regulatory network

About ۱ in ۱۱ adults worldwide now have diabetes mellitus, ۹۰% of whom have type ۲ diabetes mellitus (T۲DM). Long-term complications of diabetes develop gradually. They can eventually be disabling or even life-threatening. Macrovascular complications like heart and blood vessel disease and microvascular complications like nephropathy, retinopathy, and neuropathy.Linagliptin is a new antidiabetic drug from dipeptidyl peptidase four inhibitor (DPP۴I) class.It shows protective effects on cardiac and kidney damage, which are the most important complications of diabetes mellitus type۲. So, we intend to unveil molecular mechanisms of linagliptin's protective effects by systems biology approach.Methodology First, we searched through expression databases, including GEO, Array Express, and GEA. Other public databases also were investigated to find any kind of omics data about the drug, but due to the novelty of Linagliptin only three experimental studies were found which applied microarray, peptide mapping, and RNA sequencing techniques to decipher its effects.

کلیدواژه ها:

linagliptin ، diabetes mellitus type۲ ، regulatory network ، transcription factor ، microRNA ، motif