SARS-CoV-۲ and infection fate

Background and Aim : The novel coronavirus disease ۲۰۱۹ (COVID-۱۹) induced by severe acute respiratory syndrome coronavirus ۲ (SARS-CoV-۲) is a global pandemic, with more than one million death tolls. Immune responses have a prominent role in SARS-CoV-۲ pathophysiology. Despite the understanding of the immune response to COVID-۱۹, there are still major gaps in understanding controversial reactions and their impact on infection fate.Methods : In this review, in addition to summarizing the immune responses against SARS-CoV-۲, we propose a new perspective on how the virus induces its pathogenicity by hijacking and manipulating NK cells, Dendritic cells, T cells and B cells same as HIV-۱.Results : Following HIV-۱ entry into the host. The immune cells as well as other cells are infected and act as Trojan horses for spreading the virus. Conclusion : Therefore, based on this evidence, it would be possible antiviral HIV drugs have a positive effect on COVID-۱۹ patients.

کلیدواژه ها:

novel coronavirus ، COVID-۱۹ ، SARS-CoV-۲ ، HIV-۱ ، immune response ، infection fate.