Continuous and size-controlled preparation of ibuprofen nanosuspension using membrane crystallization method
سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 283
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شناسه ملی سند علمی:
ICNNA02_260
تاریخ نمایه سازی: 4 مهر 1400
چکیده مقاله:
This study demonstrates the continuous and low-cost synthesis of ibuprofen nanosuspension using a hand-made porous hollow fiber antisolvent crystallizer. The effect of pertinent factors, including the inlet velocity, temperature, and surfactant's concentration on the final size of nanosuspension, were systematically studied using experimental design. Statistical analysis suggested the optimal range of parameters (V=۴۵ mL/min, C=۰.۰۱۱ mM, and T=۳۰ °C) for obtaining ibuprofen nanosuspension in a size range of ۳۰۰-۴۰۰ nm desired for intramuscular injection purposes. According to the in vitro analysis, the complete release of optimized ibuprofen nanosuspension takes only ۴۰ minutes, which confirmed the enhanced dissolution rate of the synthesized drug. The obtained nanosuspension is physically stable over three months, which makes them attractive candidates for practical applications.
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نویسندگان
Atoosa Haghighizadeh
Department of polymer chemistry, kish International Campus, University of Tehran, Tehran, Iran
Hossein Mahdavi
School of Chemistry, College of Science, University of Tehran, Tehran, Iran
Omid Rajabi
Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran