Alpha-pinene improves spatial memory in Alzheimer's disease model rats
سال انتشار: 1399
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 160
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شناسه ملی سند علمی:
BIOCONF21_0671
تاریخ نمایه سازی: 7 شهریور 1400
چکیده مقاله:
Alzheimer's disease (AD) is a neurodegenerative disease that leads to memory impairment. Studies have shown that the deposition of beta-amyloid (Aβ) peptide in the brain plays an important role in the onset and progression of AD. Alpha-pinene is a type of terpene found in various plants such as pine and rosemary. Alpha-pinene can prevent oxidative stress and inflammation caused by ischemia. We studied the effect of alpha-pinene on the spatial memory of AD model rats. Adult male rats were divided into ۴ groups (۱۰ rats in each group): control, alpha-pinene, AD, and AD-alpha pinene. After intra-hippocampal injection of Aβ۱-۴۲, rats received alpha-pinene (۵۰ mg/kg) for ۱۴ consecutive days, and then, spatial learning and memory of the animals were investigated using Morris water maze. The results were analyzed using one-way analysis of variance and P <۰.۰۵ was considered as a significant level. The results showed that Aβ increased the time and distance spent to reach the hidden platform compared to animals in the control group (P < ۰.۰۵). These animals also swam less time in the target quadrant in the probe test (P < ۰.۰۱). Alpha-pinene prevented these behavioral changes in AD model rats. It is concluded that alpha-pinene can improve spatial learning and memory in animals receiving Aβ and therefore may be effective in the prevention and treatment of Alzheimer's disease.
کلیدواژه ها:
نویسندگان
Mohammad Kazem Khanmohammadi-Khorrami
Department of Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
Masoumeh Asle-Rousta
Department of Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
Mehdi Rahnema
Department of Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
Rahim Amini
Department of Biology, Zanjan Branch, Islamic Azad University, Zanjan, Iran