Protective Effect of Stachys lavandulifolia Against Seizure-induced Memory Impairment and Oxidative Stress in Experimental Models of Seizures in Rats

Stachys lavandulifolia has been used in the traditional medicine for arthritis and rheumatism disorders. Its leaf extract has also been used to treat epilepsy and other CNS disorders. To evaluate the effect of Stachys lavandulifolia extracts (SLE) on experimental models of seizure-induced memory impairment in rats. Seizures were induced in Wistar rats (۲۰۰–۲۲۰ g) by sub-threshold dose (۳۵ mg/kg) pentylenetetrazole (PTZ) every other day for one month and treated with SLE (۲۵, and ۵۰, mg/kg, intraperitoneally). After full kindling, effect on memory was assessed using passive avoidance test (PA). At the end of experiment rats were sacrificed using deep anesthesia and hippocampus was isolate for oxidative stress (malondialdehyde (MDA)) evaluation. PTZ treated groups exhibited seizures with memory deficits (p < ۰.۰۱) as compared to control group. SLE at highest dose (۵۰ mg/kg) showed protection in PTZ induced seizures. SLE also attenuated the seizure induced memory impairment as indicated by significant (p < ۰.۰۱) improvement in the retention latencies in PA as compared to PTZ treated group .In addition, treatment with the SLE protects the hippocampus by lowering the MDA level. The findings suggest that SLE exhibited significant anticonvulsant activity and preventing memory impairment by inhibition of oxidative stress damage.

کلیدواژه ها:

Kindling ، Behavioral test ، Neurodegenerative disorders ، Pentylenetetrazole