Bone Tissue Engineering; Advances and Challenges

سال انتشار: 1399
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 147

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شناسه ملی سند علمی:

BIOCONF21_0531

تاریخ نمایه سازی: 7 شهریور 1400

چکیده مقاله:

Tissue engineering is a multifaceted, interdisciplinary discipline that uses the principles of engineering sciences and natural sciences to repair the structurally and functionally damaged tissues. In order to achieve satisfactory results in tissue engineering, simulation of the natural extracellular environment is essential. To achieve thisgoal, the development of appropriate cell differentiation protocols as well as scaffold design similar to the natural matrix should be carefully considered. Stem cell differentiation into the bone line is enhanced by many inducers, including biochemical agents, biomechanical stresses, and electrical stimuli. Based on our studies, the synergistic effects of anti-mir۲۲۱, hydroxyapatite nanoparticles and electrical induction in improving the bone differentiation of mesenchymal stem cells in vivo have been confirmed. Considering the functions and positions of markers in ossification signaling pathways, it can be concluded that hydroxyapatite cooperates in allocating stem cells to bony progenitors in the early stages of ossification while electrical stimulation to more mature cells in achieves functional phenotypes. In general, the study of synergies between different stimuli and the exploitation of interactions in an optimal way can lead to the production of efficient ossification protocols for bone tissue reconstruction and engineering.

نویسندگان

Behnaz Bakhshandeh

Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran