Background and Aim : Brucellosis is an important disease between humans and animals, which is widespread throughout the country and causes economic complications and risks to public health. The diagnosis of human brucellosis is usually based on the isolation of Brucella spp. from blood, tissue and organs, the serological tests such as RBT and etc. Poor diagnosis and treatment may result in complications such as neurologic disorders and etc. The production of brucella antigen is by manual cultivation on a solid medium in RVSRI, using S۹۹ strain. However, the main barriers to improving quality and increasing production capacity are traditional production process as well as supplying necessary raw materials for antigen production .In order to obtain better performance of the production of brucella antigen to enable the improvement of diagnostic tests surveillance and reporting, a
SWOT analysis was carried out for S۹۹ production to identify weaknesses and areas that could be improved to enhance disease surveillance.Methods : In this study, a systematic review was carried out to obtain data on the strengths, the weaknesses, the opportunities and threats to S۹۹ production, using a Matrix Preparation (SWOT) of internal and external influence factors. The identified factors were then allocated to each parameter as they were determined, and discussed.Results : The results of the
SWOT analysis a based on the situational assessment of the brucella antigen production, the following gaps and challenges have been identified: Persons with experience are available for training to build capacity for improved S۹۹ antigen production and management. International Standard or references are not available to standardize antigens. Lack of extensive field studies to determine the sensitivity and specificity of production S۹۹ antigen. The infrastructure required for implementing production line for S۹۹ antigen is weak.Conclusion : The factors identified in this study could be effective and improvement through capacity building training, survey development and the use of this training in the production of S۹۹ antigen. However, this concept provides a sustained groundbreaking platform for a real change in the vaccine production paradigm towards the development of successful measures to contain the brucella diagnostic dilemma.