A Non-local Model of the Propagation of Action Potentials in Myelinated Neurons
محل انتشار: مجله ایتالیایی علوم و مهندسی، دوره: 4، شماره: 3
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 168
فایل این مقاله در 17 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJSE-4-3_001
تاریخ نمایه سازی: 25 تیر 1400
چکیده مقاله:
Myelinated neurons are characterized by the presence of myelin, a multilaminated wrapping around the axons formed by specialized neuroglial cells. Myelin acts as an electrical insulator and therefore, in myelinated neurons, the action potentials do not propagate within the axons but happen only at the nodes of Ranvier which are gaps in the axonal myelination. Recent advancements in brain science have shown that the shapes, timings, and propagation speeds of these so-called saltatory action potentials are controlled by various biochemical interactions among neurons, glial cells and the extracellular space. Given the complexity of brain’s structure and processes, the work hypothesis made in this paper is that non-local effects are involved in the optimal propagation of action potentials. A non- local model of the action potentials propagation in myelinated neurons is proposed that involves spatial derivatives of fractional order. The effects of non- locality on the distribution of the membrane potential are investigated using numerical simulations.
کلیدواژه ها:
نویسندگان
Corina.S Drapaca
Department of Engineering Science and Mechanics, Pennsylvania State University, University Park PA ۱۶۸۰۲, USA
Sahin Ozdemir
Department of Engineering Science and Mechanics, Pennsylvania State University, University Park PA ۱۶۸۰۲, USA
Elizabeth A Proctor
Departments of Neurosurgery and Pharmacology, Pennsylvania State College of Medicine, Hershey PA ۱۷۰۳۳, USA- Department of Biomedical Engineering, Pennsylvania State University, University Park PA ۱۶۸۰۲, USA