Bioinformatics approach via effect of rs8063 on UBE2I gene, hsa-miR-1237 in Hepatocellular carcinoma (HCC)

Hepatocellular carcinoma is one of the most lethal malignant tumors worldwide and one of the most common cancers in men.Surgery is the only treatment available for it; however, it can be performed only in 10-15% of patients. The development and progression of Liver cancer are primarily the results of uncontrolled regeneration of liver cells. Today, bioinformatics is used to analyze biological problems to increase our understanding of biological processes through mathematical and statistical algorithms. MicroRNAs are a small group of non-coding RNAs, ranging from 18 to 25 nucleotides in length, which can suppress the translation of proteins. Besides, SNPs are the simplest and most widely used method for determining markers in geneticstudies. Methods: This study aimed to analyze genetic factors associated with liver cancer, including the interaction between mRNA-miR-LncRNA and SNP related to this network. GEO analysis identified 250 differentially expressed genes involved in the signaling pathway of RNA transport. Results:The findings revealed that hsa-miR-1237 suppresses the UBE2I gene, and their interactions were affected by rs8063. However, this miR competes for adhesion to chr22-38_28785274-29006793.1 and KCNQ1OT1. Finally, these findings can lead to the development of an effective biomarker or diagnostic model in the diagnosis and treatment of HCC.Conclusion:The present study examines the UBE2I gene as one of the most critical genes in the development of HCC.

کلیدواژه ها:

Hepatocellular carcinoma ، Liver ، Liver cancer ، HCC ، UBE2I ، GEO ، mRNA ، miR ، LncRNA ، SNP