Preparing Biodegradable Hydrogel Based on Quince Seed Mucilage and Investigation as a Drug Delivery System

The traditional drug delivery systems created side effects in the body, due to the lack of control in the amount and selectivity of drug release. So today, many scientists are interested in a controlle release drug delivery systems and much research is being done on it. Hydrogels are usually used for this purpose1. Hydrogels are three-dimensional network hydrophilic polymers that can absorb water several times more than their dry weight. This ability depends on the structure of the polymer and the environmental factors1,2. Polysaccharide-based hydrogels are currently attracting much interest for their unique properties, that is, high water-affinity, easy procedures, biocompatibility, biodegradability, renewability, and nontoxicity, which facilitates the applications in the pharmaceutical field3. Quince seed mucilage (QCM), composed of glucuronic acid and xylose (glucuronoxylan)-based biomaterial. Glucuronoxylan is an inexpensive and biocompatible polysaccharide hydrogel which is extruded from the seeds of different plants including quince (Cydonia Oblonga)4. In this research, the synthesis of polysaccharide extracted of quince seed graft to functionalized polyvinyl alcohol (APVA) and acrylic acid (AA) copolymer have been investigated, using ammonium persulfate (APS) as an initiator. Using N, N'-methylenebisacrylamide (MBA) as a cross-linked changed copolymer to Hydrogel. The optimization was carried out using to study the effect of AA and APVA, MBA amounts, initiator concentration, temperature and time reaction based on the water absorbency capacity. Drug loading and release behavior performed on hydrogel.

کلیدواژه ها:

Polysaccharide-based hydrogels ، Quince Seed Mucilage ، Biocompatibility ، Drug delivery.