Folate chitosan-targeted mesoporous silica nanoparticles to improve rutin delivery to MCF-7 cell line

The development of specialized nanoparticles for use in the detection and treatment of cancer is increasing. These nano drug delivery systems by folic acid-mediated targeting showed improved effects because overexpression on surface of breast cancer cell line. Mesoporous silica nanoparticles (MSNs) have some properties to improve drug efficiency and bioavailability such as high drug loading capacity, controllable size and pore, large surface area, high biocompatibility, and physical stability. Rutin is a flavonoid glycoside found in many plants and it has some potential protective role for multiple diseases related to oxidative stress. Therefore, in this research MSNs use as a carrier to intelligently deliver rutin in a targeted site of MCF-7 cell line because of folate conjugated on surface nanoparticles. Based on this information, the results of this study also showed better drug performance in breast cancer cell line. The amounts of Reactive oxygen species (ROS) in cells treated with nanoparticles were less than cells treated with free rutin. These results indicate an increase in intracellular antioxidant concentration. This indicates an increase in the antioxidant effect of this drug which disrupts the use of cancer cells from ROS to increased cancer cell death. The results also show that by increasing drug delivery to cancer cells by MSNs, cellular nitric oxide (NO) levels increased. This drug affects the pathways of NO synthesis so by increased delivery of rutin which effect on synthesis of NO and more cancer cell death.

کلیدواژه ها:

mesoporous silica nanoparticles ، rutin ، chitosan ، folate