مطالعه تجربی اثرات سم عقرب مزوبوتوس اوپئوس بر غلظت پلاسمایی هورمون های متابولیک و گلوکز در موش صحرایی

سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 487

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شناسه ملی سند علمی:

JR_IJVM-14-1_007

تاریخ نمایه سازی: 21 فروردین 1399

چکیده مقاله:

BACKGROUND: Mesobuthus eupeus is an indigenous scorpion species in Southwest Iran which is respon- sible for the majority of scorpion sting cases in Khuzestan province. OBJECTIVES: The effects of M. eupeus venom were investigated on the chief metabolic hormones in rats. METHODS: A total of 45 Albino male rats were divided into 3 equal groups: group 1 (control): 0.5 ml normal saline was administered intraperitoneally (IP); group 2 and 3: M. eupeus venom was administered with a dose of 1 and 2 mg/kg IP, respectively. Sampling was performed at 8, 24, and 48 hours after venom/ saline injection. RESULTS: The levels of thyroxine (T4) and triiodothyronine (T3) were significantly lower in both venom receiving groups (groups 2 and 3) than in the control group, dose-dependently, at all sampling times. There was a significant decrease in insulin level in both intoxicated groups compared to the control group at all sampling times. Glucagon, cortisol and subsequently glucose concentrations were significantly increased in both groups receiving the venom (groups 2 and 3) compared to the control group at 8 and 24 hours following envenomation. CONCLUSIONS: The findings of this study indicate that M. eupeus venom can suppress the secretion of essential metabolic hormones including T3, T4, and insulin and stimulate the release of glucagon, and cor- tisol, leading to hyperglycemia.

نویسندگان

Mohammad Razi Jalali

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz,Iran

Seyedeh Missagh Jalali

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Hedieh Jafari

Department of Venomous Animals and Toxins, Razi Vaccine and Serum Research Institute, Ahvaz, Iran

Mohammad Babakhan

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

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  • Andrade, M.V., Caramez, M.P.R., Abreu, E.M.N., ...
  • Dolnikoff, M., Omar, E.D., Velasco, I.T., Cunha-Melo, J.R. (2004) Lung ...
  • Dehghani, R., Rafinejad, J., Fathi, B., Shahi, M.P., Jazayeri, M. ...
  • Erdeş, E., Doğan, T.S., Coşar, İ., Danışman, T., Kunt,  K.B.,  ...
  • C. (2014). Characterization of Leiurus abdul- lahbayrami   (Scorpiones:   Buthidae)  venom: ...
  • peptide profile, cytotoxicity and antimicrobial activity. J Venom Anim Toxins ...
  • Jalali, A. and Rahim, F. (2014). Epidemiological review of scorpion ...
  • Johnson, D.G., Ensinck, J.W. (1976). Stimulation of glucagon secretion by ...
  • https://doi.org/10.2337/diab.25.8.645 ...
  • Khoobdel, M., Zahraei-Salehi, T., Nayeri-Fasaei, B., Khosravi, M., Omidian, Z., ...
  • Ladjel‐Mendil, A., Martin‐Eauclaire, M.F., Lar- aba‐Djebari, F. (2016). Neuro‐Modulation of ...
  • Laraba-Djebari, F., Adi-Bessalem, S. and Ham- moudi-Triki, D. (2015). Scorpion ...
  • Springer, Dordrecht. pp 63-85. https://doi. org/10.1007/978-94-007-6404-0_2 ...
  • Lourenço, W.R.  (2014).  A  historical  approach to scorpion studies with ...
  • Lucas, S.M. and Meier, J. (2017). Biology and dis- tribution ...
  • More,  S.S.,  Kiran,  K.M.,  Gadag,  J.R.    (2004). ...
  • Dose-dependent serum biochemical alter- ations  in  Wistar  albino  rats  after ...
  • gravimanus (Indian black scorpion) envenom- ation. J Basic Clin Physiol ...
  • Murthy, K.R.K., Zare, M.A. (2002). Scorpion antivenom reverses metabolic, electrocardio- ...
  • Murthy, K.R.K. (2000). The scorpion envenoming syndrome: a different perspective. ...
  • Murthy, K.R.K., Zare, M.A. (1998). Effect of In- dian red ...
  • Murthy, K.R.K, Zare, M.A. (2001). The use of an- tivenom ...
  • Murthy, K.R.K. (2013). Treatment of Scorpion Envenoming Syndrome—Need for Scientific ...
  • Murthy, K.R.K. (2014a). Cardiac Sarcolemmal Defects in acute myocarditis due ...
  • Murthy, K.R.K. (2014b). Enzymes and toxins in scorpions of Buthidae ...
  • Murthy, K.R.K., Haghnazari, L. (1999). The blood levels of glucagon, ...
  • Murthy, K.R.K., Shenoi, R., Vaidyanathan, P., Kelkar, K., Sharma, N., ...
  • Murthy, K.R.K., Vakil, A.E. and Yeolekar, M.E. (1990) Insulin administration ...
  • Murthy, K.R.K., Vakil, A.E., Yeolekar, M.E., Va- kil, Y.E. (1988). ...
  • Nencioni, A.L.A., Neto, E.B., de Freitas, L.A., Dorce, V.A.C. (2018). ...
  • Petricevich,   V.L.   (2010).   Scorpion   venom  and  the   inflammatory   response.   Media- ...
  • org/ 10 .1155 / 2010/ 903295 ...
  • Rahmani, A.H., Forouzandeh, H., Kalantar, M.,Asad-Masjedi, N., Alavian, Z. and ...
  • Rahmani, A.H., Jalali, A. (2012). Symptom pat- terns in adult ...
  • (4), 427-431. http://dx.doi.org/10.1590/ S1678-91992012000400011 ...
  • Razi Jalali, M., Jalali, M.T., Mapar, Z. (2015). Evaluation of ...
  • Razi jalali, M., Jalali, S.M., Najafzadeh Varzi, H., Shokraeian, A.A. ...
  • Sadeghian, H. (2003). Transient ophthalmople- gia following envenomation by the ...
  • http://doi.org/10.1212/01.wnl.00000 44158.90246.9f ...
  • Sengupta, S., Dhanapal, P., Ravindran, R.D.,  Devi, N. (2009). Cerebral ...
  • Seyedian, R., Hoseiny, S.M., Kamyab, M., Mans- ury, R., Seyedian ...
  • Taibi-Djennah, Z., Laraba-Djebari, F. (2015). Ef- fect of cytokine antibodies ...
  • Thomas, V.V., George, T., Mishra, A.K., Man- nam, P., Ramya, ...
  • Yugandhar, B., Murthy, K.R.K., Sattar, S.A. (1999). ...
  • Insulin administration in severe scorpion en- venoming. J Venom Anim ...
  • Zare, M.A., Murthy, K.R.K., Haghnazari, L. (1994). Scorpion venom poisoning ...
  • نمایش کامل مراجع