HN-02390255_The Role of Fasting for Treatment and Prevention of Cancer; Where Do We Stand Now

Introduction: In the USA, one out of every four deaths reported to be due to cancer. More than 35% of all types of cancer reported to preventable through modification of lifestyle. Several studies showed that fasting has the potential role for preventing and treating different diseases. The aim of present study was to evaluate possible role of fasting diet for treating different types of cancers.Methods: Three different electronic database including PubMed, ISI Web of Science and Scopus and also clinical trial registration platform searched up to February 2020 for finding related human studies which evaluate the effect of fasting in patients with different types of cancer.Results: Although no randomized controlled trials are available which evaluate the effect of fasting in cancer prevention and treatment, other research supports the potential efficiency of fasting in cancer prevention and treatment. In a pilot study, three monthly fasting cycles decreased the percentage of mesenchymal stem and progenitor cells in the peripheral blood mono-nucleated cell population, fasting blood glucose andinsulin growth factor (IGF)-1 levels. Elevated circulating IGF-1 is associated with increased risk of developing certain cancers. Several studies reported the effect of fasting on decreasing side effects of cancer treatment. A number of trials are now trying to evaluate the effects of fasting on sensitizing cancer cells to the treatment.Conclusion: Despite several preclinical and pilot clinical trials regarding possible beneficial role, however before confirm conclusion could be drawn randomized controlled trials with large scale design is needed.

کلیدواژه ها:

Cancer ، Neoplasia ، Fasting ، Intermittent Fasting