HN-02320246_The Survey ofThe Effect ofHMB (Β-Hydroxy Β-Methyl Butyrate) Supplementation on The Risk of Sarcopenia among Old Age Patients

Introduction: Sarcopenia is a muscle-wasting disorder that causes negative-protein balance in the skeletal muscles by replacing lean body mass (LBM) with fat-mass (FM). Both women and men older than 65 years are vulnerable to sarcopenia. β-hydroxy β-methyl butyrate (HMB), which naturally derives from leucine in the body, is one of the essential amino acids that can have a significant effect on muscle turn-over. Regarding the HMB biological function, we evaluated the effect of HMB supplementation on the risk of sarcopenia among geriatrics.Methods: A search on published articles from 2010 to 2020 in PubMed, Google Scholar, web of science, and Scopus was performed using the following search keywords; HMB, sarcopenia, sarcopenic obesity, treatment, prevention, and old age. Search resulted in 48 articles that 17 articles (6 originals and nine reviews) were reviewed after implementing the inclusion and exclusion criteria.Results: HMB supplementation had a beneficial effect in preventing muscle wasting in the elderly. Both resistance exercise and HMB supplementation could prevent sarcopenia (pro: > 1g/bwt) (p<0.001). HMB supplementation improved muscle wasting by increasing the myogenesis, decreasing muscle apoptosis, and refining muscle turnover. Daily administration of HMB and other amino-acids (totaling 3 g HMB, 14 g Arginine, 14 g Glutamine) during six months could increase LBM in geriatric population (P = 0.016).Conclusion:In the standard health status, HMB supplementation, essential amino acids, and regular resistance exercise not only prevent sarcopenia but also could improve sarcopenia in the elderly.

کلیدواژه ها:

sarcopenia ، sarcopenic obesity ، old ages ، HMB ، amino-acid supplementation ، treatment ، prevention ، geriatrics ، and lean body mass (LBM)