HN-01830158_The effect of vitamin D supplementation on serum level of heat shock protein 60 in coronary heart disease patients: A randomized clinical trial

Introduction: This study was aimed to investigate the effect of vitamin D supplementation on Heat Shock Protein-60 (HSP-60) and other inflammatory markers (IL-17, TNF-α, PAB) in patients with coronary heart disease.Methods: In this double blind randomized clinical trial, we recruited 80 male and female patients aged 30-60 years old with coronary heart disease and 25(OH)D3 <30 ng/ml, from Rasool-e-Akram Hospital in Tehran, Iran. Serum levels of 25(OH)D3, HSP 60, IL-17, TNF-α, PAB, lipid profiles and PTH were measured both in the baseline and termination of intervention. Eligible participants were randomly assigned in placebo or intervention group to receive vitamin D supplement (50,000 IU/wk) or placebo for 8 weeks. Results: The results demonstrated that vitamin D supplementation resulted in significant increase in serum level of 25 (OH) D3 (46.86 vs 7.28 ng/ml) comparing placebo group. Parathyroid Hormone (PTH) also decreased among intervention group after 8-week supplementation (-19.81 vs 2.92 pg/ml). Change in waist circumfrence (-0.97 vs -0.26 cm), fat percentage (-1.13 vs 0.1 %), systolic blood presure (-3.85 vs -2.11 mmHg) and dyastolic blood presure (-4 vs -1.86 mmHg) were significant in the vitamin D group (all P-values < 0.05). Other variables did not significantly change after intervention.Conclusion: Based on our findings in this study, supplementation of vitamin D with a weekly dose of 50000 IU for 8 weeks, in patients with coronary heart disease represented dicreased systolic and diastolic blood pressure, waist circumference and fat percentage. Whereas, it had no significant effect on heat shock protein 60, inflammatory markers and lipid profiles.

کلیدواژه ها:

Vitamin D supplementation ، Coronary heart disease ، Heat shock protein 60