Effect of resveratrol and quercetin on Colon Cancer

Back ground and Aim :Cancer is one of the most common diseases at the world. 1 out of 8 deaths at the world happen as a result of cancer. Cancer is the third cause of mortality in Iran. Colon cancer is the fourth cause of mortality at the world and annually 1.2million people with the disease are being diagnosed. About 8% of overall mortality rate is as sociated with colon cancer. Colon cancer has been considerably increased in Iran over the 3 decades and it is the second common cancer in Iran according to annual report of National Cancer Institute of Iran Materials and Methods: The present study is designed to investigate the preventive effects of polymeric resveratrol and quercetin on colon carcinogenesis in an azoxymethane-in duced rat tumor. Fifty five rats were divided equally into healthy, control, resveratrol, quercetin and combination of resveratrol and quercetin treated groups. Animals received azoxymethane AOM as a carcinogenic agent weekly for two consecutive weeks other than healthy group . They were given resveratrol and quercetin two weeks before till 14 weeks after the last injection of AOM. In the end, histopathological and immunohisto.chemistry examinations were performed on colon tissue Results: The cytological and morphological changes of the cells healthy group were sig nificantly lower compared to other groups that indicates the carcinogenous effect of azoxymethane medicine. Beta-catenin proteins expression was lower in the combination In addi- . 001.of resveratrol and quercetin group in compare-son with control group P<0 tion Axin expression was significantly increased in combination of resveratrol and quer. 001.cetin in comparison with control -treated group P<0 Conclusion: The present study demonstrated the potential anticancer effects combination .of resveratrol and quercetin in a typical animal modelColon Cancer

کلیدواژه ها:

Resveratrol ، Quercetin ، Beta-catenin ، Axin.Colon Cancer