Serum anti-Müllerian hormone is associated with oocyte dysmorphisms and ICSI outcomes

Background and Aim : Objective: To evaluate the association between serum levels of anti-Müllerianhormone (AMH) and oocyte dysmorphisms in intracytoplasmic sperm injection (ICSI) cycles.Methods : Methods: A retrospective study of data from 628 ICSI cycles with successful oocyte retrievalcarried out at a single center in Tehran from November 2015 to July 2018. Cycles were divided into sixgroups by serum AMH level. Various oocyte dysmorphisms, quantity of retrieved oocytes, fertilizationrates, cleavage-stage embryos, and pregnancy rates were compared among the groups.Results : Results: Serum AMH was associated with cytoplasm granulation, abnormally amorphous oocytes(P˂0.01), extended perivitelline space (P˂0.001), granulated perivitelline space (P˂0.05), fragmented polarbody (P˂0.001), and average of oocyte quality index (AOQI) (P˂0.01). The total number of aspirated andmetaphase ΙΙ oocytes increased with increasing AMH levels (P<0.001). There was no difference in the rateof fertilization or cleavage-stage embryos among the study groups; however, the pregnancy rate differedsignificantly (P<0.05).Conclusion : Conclusions: Serum levels of AMH were associated with specific oocyte dysmorphisms andAOQI. Serum AMH levels might influence both qualitative and quantitative aspects of the ovarian responseto stimulation and also the pregnancy rate in ICSI cycles.

کلیدواژه ها:

AMH ، Anti-Müllerian hormone ، ICSI outcomes ، Intracytoplasmic sperm injection ، Oocyte dysmorphisms ، Oocyte quality ، Oocyte quantity ، Ovarian response