The effect of platelet-rich plasma on pregnancy outcomes in infertile women with recurrent implantation failure: A randomized controlled trial

Introduction: Recurrent implantation failure is an important issue in assisted reproduction and despitevarious treatment that have been described before, there is no agreement on which is the best option.This study was directed to assess the efficacy of autologous platelet-rich plasma (PRP) on pregnancy ratein recurrent implantation failure.Methods: Between 2016 till 2019, a total of 98 women who unsuccessful to be pregnant after 3 or higherquality embryo transfers undergoing frozen-thawed embryo transfer with or without intrauterineinfusion of PRP. 0.5 ml of PRP at 4–6 times higher concentration than peripheral blood infusedintrauterine 72 hours before embryo transfer. A control group underwent standard protocol.Results: There were no significant differences between the two groups in terms of age, body mass indexand duration and cause of infertility and total transferred embryos and kind of treatment protocol. Butsecondary infertility and endometrial thickness 96 h before embryo transfer, was more in interventiongroup. The clinical pregnancy (52.73% versus 23.26; P= 0.003) and implantation rate (21.74% versus11.36%; P= 0.019) was more significant in the intervention group rather than controls.Discussion: In conclusion, intrauterine infusion of platelet-rich plasma 72 hours instead of 48 hoursbefore freeze-thawed embryo transfer may have more effectiveness in in vitro fertilization (IVF)outcomes in recurrent implantation failure.

کلیدواژه ها:

Platelet-Rich Plasma ، Fertilization in Vitro ، Pregnancy Rate ، Sperm Injections ، Intracytoplasmic ، Blastocyst Transfer