Preventive Gynecology Research Center,Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 405

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شناسه ملی سند علمی:

DTOGIMED03_027

تاریخ نمایه سازی: 26 بهمن 1398

چکیده مقاله:

Systemic lupus erythematosus (SLE) is a chronic, multisystem, inflammatory, autoimmune diseaseof unknown origin characterized by the production of non organ specific auto antibodies and abroad spectrum of clinical and immunological manifestations that can involve joints, kidneys, seroussurfaces, and vessel walls. The course of SLE is highly variable, but exacerbation and remissionperiods are often present .. The etiology of the disease is unknown, but the role of female hormonesis unquestionable, as 90% of those affected are women. As prognosis has improved, more cases ofSLE women at child-bearing age are detected. The APS is also more common in women. in theabsence of severe disease and with a normal ovarian function, fertility in women with lupus is similarto that of the general population. Some, retrospective, reports have suggested a relationshipbetween antiphospholipid antibodies and infertility and poor ART outcome . when the disease isknown, a planned ovarian stimulation with co-administration of prophylactic therapy (especially,anticoagulation for thrombotic complications and corticosteroids for lupus activity)during aremission phase can reduce the complication rate in these patients, leading to a safe and successfultreatment; and when the disease is unknown there is an increased risk of thrombotic or lupus flarecomplications. Perhaps the most threatening condition associated with ovarian stimulation inwomen with SLE and APS is thrombosis. Therefore, the risk of thrombosis would be really increasedonly in women with thrombophilia or a history of a thromboembolic event. thrombosis tended todevelop as part of an overt OHSS . At present, no specific approach or type of gonadotropin hasbeen shown to offer a clear advantage in the prevention of thrombosis. Considering that most casesof thromboembolic complications (TEC ) appear after hCG administration and in association withovert OHSS the main aim in women affected by SLE/APS should be to avoid OHSS by using availablepreventive strategies .

نویسندگان

Nasrin Saharkhiz

Preventive Gynecology Research Center,Imam Hossein Hospital, Shahid Beheshti University ofMedical Science, Tehran, Iran