New derivatives of amidoalkyl-2-naphthols as a novel series of antibacterial agents

Introduction and Obejectives: Amidoalkyl-2-naphthols are an important group of molecules as they can easily convert to oxazine derivatives with different possible medical applications such as antitumor, antimalarial and antibiotic properties. In this study, antimicrobial activity of new derivatives of amidoalkyl-2-naphthols was assessed using disk diffusion method. Materials and Methods: Antimicrobial activity of the derivatives was assessed against two medically important bacteria: Staphylococcus aureus and Acinetobacter baumannii (Gram positive and Gram negative, respectively). Disk diffusion method was performed according to the latest version of the CLSI Method using 100 mg/ml concentration of each compound. After 24 hours of incubation, antibacterial activity was measured as inhibition zone diameter. An inhibition zone diameter of 10 mm was arbitrarily chosen to represent bacterial susceptibility to the compounds. Results: Out of 53 recruited compounds, 17 displayed antimicrobial activity. While three compounds were effective against both S. aureus and A. baumannii, 13 were only effective against S. aureus and one only against A. baumannii. Conclusion: Derivatives of amidoalkyl-2-naphthols could be effective antibacterial agents. As S. aureus and A. baumannii can cause nosocomial infection, further studies are needed to evaluate the therapeutic potential of the studied compounds in infectious diseases.

کلیدواژه ها:

amidoalkyl-2-naphthols ، antimicrobial agents