Accuracy of modification of diet for renal disease and Cockcroft-Gault equations as compared to the radioisotope double sample method: A study in patients with acute renal failure

سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 315

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شناسه ملی سند علمی:

JR_IRJNM-22-1_005

تاریخ نمایه سازی: 21 بهمن 1398

چکیده مقاله:

Introduction: We intended to assess the accuracy of re-expressed Modification of Diet for Renal Disease (MDRD) and Cockcroft-Gault (CG) equations to estimate glomerular filtration rate (GFR) in chronic kidney disease in two different etiologies of acute renal failure (ARF): acute tubular necrosis (ATN) and acute glomerulonephritis (AGN). Methods: Patients admitted for ARF or the patients complicated with ARF during the course of their hospitalization were enrolled to the study (n=21; 14 females and 7 males; 11 ATN and 12 AGN). When the plasma creatinine reached a steady state (DPSM) using 99mTc-DTPA. GFR was also estimated by MDRD (GFRMDRD) and CG (GFRCG) equations. Results: The patients aged 44.8±19.5 years and weighted 67.8±10.7kg. GFRDPSM (32.9±14.7 ml/min) was statistically different from the GFRMDRD (11.6±8.2 ml/min; pCG was lower than GFRDPSM in patients with either ATN (16.5±12.5ml/min and pDPSM and GFRMDRD (r=0.34; p=0.13) but GFRDPSM and GFRCG values were correlated (r=0.48; p=0.03). Out of subjects with GFRDPSM > 30, 92.3% had GFRMDRDCG Conclusion: Our results indicate that MDRD and CG equations were substantially inaccurate in patients with ARF.   More precise methods of GFR evaluation is recommended in these patients.

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نویسندگان

Alireza Emami-Ardekani

Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

Babak Fallahi

Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

Manoochehr Amini

Department of Nephrology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Armaghan Fard-Esfahani

Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

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