Alireza Emami-Ardekani - Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
Babak Fallahi - Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
Manoochehr Amini - Department of Nephrology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Armaghan Fard-Esfahani - Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

Introduction: We intended to assess the accuracy of re-expressed Modification of Diet for Renal Disease (MDRD) and Cockcroft-Gault (CG) equations to estimate glomerular filtration rate (GFR) in chronic kidney disease in two different etiologies of acute renal failure (ARF): acute tubular necrosis (ATN) and acute glomerulonephritis (AGN). Methods: Patients admitted for ARF or the patients complicated with ARF during the course of their hospitalization were enrolled to the study (n=21; 14 females and 7 males; 11 ATN and 12 AGN). When the plasma creatinine reached a steady state (DPSM) using 99mTc-DTPA. GFR was also estimated by MDRD (GFRMDRD) and CG (GFRCG) equations. Results: The patients aged 44.8±19.5 years and weighted 67.8±10.7kg. GFRDPSM (32.9±14.7 ml/min) was statistically different from the GFRMDRD (11.6±8.2 ml/min; pCG was lower than GFRDPSM in patients with either ATN (16.5±12.5ml/min and pDPSM and GFRMDRD (r=0.34; p=0.13) but GFRDPSM and GFRCG values were correlated (r=0.48; p=0.03). Out of subjects with GFRDPSM > 30, 92.3% had GFRMDRDCG Conclusion: Our results indicate that MDRD and CG equations were substantially inaccurate in patients with ARF.   More precise methods of GFR evaluation is recommended in these patients.

Acute glomerulonephritis, Acute tubular necrosis, Acute renal failure, Cockcroft-Gault equation, Double plasma sample method, Diet