Apigenin prevents methotrexate‐induced kidney oxidative damage in rats

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 349

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شناسه ملی سند علمی:

TOXICOLOGY15_220

تاریخ نمایه سازی: 15 بهمن 1398

چکیده مقاله:

IntroductionMethotrexate is used as an effective chemotherapeutic agent against different autoimmune diseases and tumors. According to several studies, oxidative stress and inflammation are involved in the pathogenesis of MTX-induced damage in different organs, especially the kidney. This study aimed at examining the ameliorating effects of apigenin on oxidative stress and inflammation due to MTX treatment in the kidney of rats.Methods The rats were classified into four experimental groups. The levels of cratinine (Cr), blood urea nitrogen (BUN) were measured in the collected blood samples. In kidney tissues, the levels of MDA, NO, CAT, GSH, GPx, and SOD along with TNF-α and IL-1β, were assessed. Results The API pretreatment group showed a significant rise in kidney antioxidants markers, besides significant reductions in the serum levels of Cr, BUN and kidney content of MDA, TNF-α, NO, and IL-1β. Based on the findings, API can prevent nephrotoxicity through mitigation of oxidative stress and inflammation.Discussion & Conclusion Our findings revealed that API can the improvement of MTX- induced nephrotoxicity by reducing inflammation and improving the oxidative status. The exact mechanism of API should be identified in future studies.

نویسندگان

Hadi Kalantar

Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran- Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Mojtaba Kalantari

Student Research Committee, Shoushtar University of Medical Sciences, Shoushtar, Iran

Mehdi Goudarzi

Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Mojtaba Haghi Karamallah

Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran