Protective effect of Quercetin against oxidative stress induced by Bisphenol-A in Rat Liver Mitochondria

Introduction: Recognized as a distinguished environmental and global toxicant, Bisphenol A (BPA) affects the liver, which is a vital body organ, by the induction of oxidative stress. The present study was designed to Protective effect of Quercetin against BPA in hepatotoxicity in Wistar rats and the commotion of mitochondrial activities of enzymes were evaluated. Methods: To this end, 32 male Wistar rats were divided into four groups (six rats per group), including control, BPA (250 mg/kg), BPA + Quercetin (75 mg/kg) and Quercetin (75 mg/kg). Results: The BPA -induced alterations were restored in concentrations of alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) due to the Quercetin treatment (75 mg/kg) (All P<0.001). While the levels of mitochondrial membrane potential (MMP), reactive oxygen species (ROS), and malondialdehyde (MDA) decreased by the Quercetin treatment in the liver mitochondria (P<0.001), the Catalase (CAT) and glutathione (GSH) increased (p<0.001). Discussion: According to the results, the potential hepatotoxicity of BPA can be prevented by Quercetin, which protects the body against oxidative stress and BPA-induced biochemical. Moreover, the reproductive toxicity of BPA after environmental or occupational exposures can be potentially prohibited by Quercetin.

کلیدواژه ها:

Liver ، Mitochondria ، ROS ، Oxidative stress ، Bisphenol A ، Quercetin