Investigating the Effect of Zingerone on Cisplatin-Induced Oxidative Stress of Liver Damage in Rats

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 284

نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

TOXICOLOGY15_098

تاریخ نمایه سازی: 15 بهمن 1398

چکیده مقاله:

Introduction: Cisplatin is known as one of the most significant anticancer medications, which is being extensively used to treat a wide range of cancers. However, it can bring about complications such as hepatotoxicity at high doses. Since Zingerone, as an active ingredient of a ginger plant, is characterized by antioxidant properties, its protective effect on cisplatin-induced hepatotoxicity was investigated in this study. Methods: The animals recruited in the present study were assigned randomly to six groups including control group (Group I); cisplatin group (Group II) reciveing 7.5 mg/kg of this medication intraperitoneally on the fourth day; Group III treated with a 50 mg/kg dose of Zingerone during one week; and Groups IV, V, and VI taking Zingerone doses of 10, 20, and 50 mg/kg, respectively, for a week, and subsequently receiving cisplatin at a dose of 7.5 mg/kg intraperitoneally on the fourth day. After 72 h; thee given animals were anesthetized, and then serum response factors (SRFs) were investigated using blood samples taken from these animals. As well, one liver lobe was used for histopathological assessment, while the other lobe was employed to measure oxidative stress parameters. Results: The findings revealed that Zingerone had produced a significant reduction in the activity of serum aspartate aminotransferase (AST) in the groups reciveing this medication compared with the cisplatin group. Examining the levels of oxidative stress, a significant decline was also observed in elevated superoxide dismutase (SOD) activity, malondialdehyde (MDA) of the liver tissue, and glutathione peroxidase (GPX) enzymes in the groups taking Zingerone in comparison with the cisplatin group. Discussion: The results of this study indicated that Zingerone prevents hepatotoxicity developed in Wistar male rats in a dose-dependent manner. Furthermore, it is suggested that Zingerone is able to protect the liver against cisplatin-induced hepatotoxicity due to its antioxidant effects.

نویسندگان

Zahra Heibati

Medicinal Plants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Mohammad Javad Khodayar

Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran- Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Layasadat Khorsandi

Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Maryam Salehcheh

Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran