Comparison of the analgesic effects of intraoperative NASID and Nerve on post-operative pain in dental surgeries in dogs

Background and Objective: Dental Procedures that tend to cause pain can be resolved through local nerve blocks. Majority of Different anesthetic products used in all forms of surgery still have the tendency to feel pain. Therefore, use of an analgesic regimen in anesthetic protocols is recommended. Also due to inflammation of the oral tissues, using NSAIDs drugs in post operative managements is effective.Materials and Methods: 10 healthy and adult dogs from both sexes entered the study. General anesthesia was performed by intramuscular injection of Acepromazine (0/01 mg/Kg) as the pre-anesthesia and intravenous drug Ketamine and Medetomidine integration (8 mg/kg and 30μg/Kg). After tracheal intubation and connection to inhalation devices, the rate of 1/2 % Isoflurance in 1 liter of oxygen was transferred to the patient and anesthesia continued. Preparation of the oral cavity was performed with 0.2 % chlorhexidine. The dogs were divided randomly into two groups of five dogs. In the first group (PG) intravenous administration of the drug meloxicam (0.2 mg/Kg) was done, after induction of anesthesia. In the Second group (LG) local anesthesia was applied by integration of Lidocaine 2% with Epinephrine 1/80000 (1 mg/Kg) and bupivacaine 2% (1mg/Kg), after induction of anesthesia. Then lateral incisors pulpotomy surgery was performed in both groups. Venous blood samples from all of the patients were collected before anesthesia (time zero), in the middle of anesthesia (30 minutes), 3 hours and 24 hours after induction. After separation of serum, samples were sent to the laboratory to measure the amount of cortisol. In addition, the post-operative pain was measured before surgery, at 3,5 and 24 hours after surgery by UPMS method. Pain rating was recorded for each dog at different times in the pre-designed table.Finding: Interpretation of the results related to pain scores in both study groups showed that at zero hours, all patients were clinically free of dental pain. In three hours and 24 hours after undertaking there was no significant difference in pain score between the two groups (P> 0.05). But at 5 hours after surgery, pain score in LG group was significantly lower than PG group (P=0.02). The process of registration of pain in the group LG reduced clinically, as time passes. But, in the group PG pain scores after 3 and 5h after surgery increases. In both groups, 24 hours after surgery pain decreased significantly but the mean score in the group PG is still higher than LG, 24 hours after surgery, although there was no significant difference between them (P<0.05). Evaluation of cortisol in different times showed that there wasn’t significant difference between the two groups in level of cortisol at time zero before causing painful stimuli. 30 minutes after the start of the surgery, cortisol level in LG group was significantly lower than PG group (P=0.001). Cortisol levels at 24 hours after the surgery for the LG group was lower than PG (P=0.0001).Conclusion: As a result, nerve block by using the combination of Lidocaine and bupivacaine in dental surgery pain control is more effective than perioperative administration of Meloxicam

کلیدواژه ها:

Analgesia ، Local block ، NSAID ، dental surgery