Investigation of the interaction of natural compounds with senp1 protein

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 415

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شناسه ملی سند علمی:

CIGS15_587

تاریخ نمایه سازی: 13 بهمن 1398

چکیده مقاله:

Introduction: SUMO proteins regulate many cellular processes by attaching covalane to the substrate and sumoylation (1)(2). Sumoylation is a reversible process that is performed by SENP proteases (3).Disturbances or changes in SUMO is correlated with a variety of diseases including cancers (prostate and thyroid), neurodegenerative syndromes, diabetes, viral infections and related growths (1) (5) (4) (6)HIF-1α desumoylation by SENP1 under hypoxia conditions increases the HIF-1α stability and increases the expression of target genes of this factor (7).SENP1 enables another oncoenic signaling pathway, such as androgenetic receptor transcription. This information and the rest of the information indicates the potential importance of SENPs as diagnostic markers and also makes this category of enzymes an interesting therapeutic goals in which is identified in human tumors SENP1 causes the desumoylation of HDAC1, P300 and AR (8) (9) (10). Natural products are capable of removing ROS and protecting cellular components like DNA, proteins and lipids from oxidative stress (11).Discussion and Conclusion: smaller Compounds such as betanidin, or with the many electrostatic and van der waals interactions, Like caffeic acid, they showed lower binding energy and stronger interactions.

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نویسندگان

Somayeh Taghvaei,

National Institute of Genetics Engineering and Biotechnology

Farzaneh Sabouni,

National Institute of Genetics Engineering and Biotechnology

Zarrin Minuchehr

National Institute of Genetics Engineering and Biotechnology