Overexpression of lnc-RNA SNHG7 promotes the proliferation, migration and invasion in 10 patients with colorectal cancer(CRC)

Since Colorectal cancer is third in the cancer morbidity, its important to identify novel bio-markers that can identify the bio logical characteristics of tumors and predict prognosis in patients with CRC. About 90% of the genome(non-coding RNA genes) is transcribed into non-coding RNA that cannot be translated into proteins. LncRNAs may play important roles in carcinogenesis, function as oncogenes or anti-oncogenes , and their dysregulated expression is significantly correlated with carcinogenesis (development ,prognosis, metastasis, and recurrence in different cancer types). Therefore, they may be considered to be promising candidate biomarkers for diagnosing cancer and may also represent therapeutic target.In this study, we analysed one lncRNA( SNHG7) expression in corolectal cancer tissues compared to, in 10 patients by qRT-PCR (P=0.046).Materials and methods We extracted total RNA from 10 paired tissues(CRC and adjacent noncancerous tissues) , then reverse transcribed RNA to cDNA, and finally we analized expression by qRT-PCR(Real-time PCR).Result We found that the expression levels of lncRNA-SNHG7 was obviously upregulated in CRC(P=0.046).Discussion In this study, we analyzed Long non-coding small nucleolar RNA host gene 7 (lncRNA SNHG7) expression in corolectal cancer tissues compared to adjacent noncancerous tissues, in 10 patients. LncRNA-SNHG7 was obviously upregulated in CRC.According to previous studies , lncRNA-SNHG7 can potentially promotes the proliferation, migration and invasion, suggesting that lncRNA-SNHG7 as a key regulator of gene expression, may be a promising therapeutic strategy for the treatment of CRC tissues ,of course more samples should be analized.

کلیدواژه ها:

SNHG7 ، Long non coding RNAs ، Expression ، Colorectal cancer