ZIC3 mutations in Iranian patients with congenital heart defects

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 340

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شناسه ملی سند علمی:

CIGS15_489

تاریخ نمایه سازی: 13 بهمن 1398

چکیده مقاله:

Introduction: Congenital heart defect is one of the most common abnormalities in the neonates which occur due to heterozygous causes. The ZIC3 gene is one of the genes involved in congenital heart defects. Therefore, this study was conducted to evaluate the role of ZIC3 gene in congenital heart disease in Iranian population.Materials and Methods: In this study, clinical and cardiac symptoms including echocardiography were evaluated in 50 Iranian patients with congenital heart defect. The ZIC3 gene was sequenced in these patients. The samples were collected from patients referring to Shahid Rajaie Heart Hospital during the years 1969-1959. Results: CHD was confirmed by echocardiogram. 48% of affected individuals had complex form and the remaining had simple form of CHD. The sequencing results showed that none of the patients had ZIC3 mutation.Discussion: ZIC3 gene does not play an important role in the Iranian population. Other genes probably cause CHD in this population.

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نویسندگان

Maryam Pourirahim

Masters student, Molecular Cell Group, Faculty of Life Sciences, Tehran University, Tehran, Iran

Elahm Siasi

Masters student, Molecular Cell Group, Faculty of Life Sciences, Tehran University, Tehran, Iran

Samira Kalayinia

Department of Genetics and Molecular Medicine, Faculty of Medicine, Zanjan University of Medical Sciences

Majid Maleki

Genetic Research Laboratory, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Zahra Maleki

Genetic Research Laboratory, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Nejat Mahdieh

Genetic Research Laboratory, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran