ZIC3 mutations in Iranian patients with congenital heart defects

Introduction: Congenital heart defect is one of the most common abnormalities in the neonates which occur due to heterozygous causes. The ZIC3 gene is one of the genes involved in congenital heart defects. Therefore, this study was conducted to evaluate the role of ZIC3 gene in congenital heart disease in Iranian population.Materials and Methods: In this study, clinical and cardiac symptoms including echocardiography were evaluated in 50 Iranian patients with congenital heart defect. The ZIC3 gene was sequenced in these patients. The samples were collected from patients referring to Shahid Rajaie Heart Hospital during the years 1969-1959. Results: CHD was confirmed by echocardiogram. 48% of affected individuals had complex form and the remaining had simple form of CHD. The sequencing results showed that none of the patients had ZIC3 mutation.Discussion: ZIC3 gene does not play an important role in the Iranian population. Other genes probably cause CHD in this population.

کلیدواژه ها:

ZIC3 ، mutation ، congenital heart defects